Read and carefully follow any instructions for use provided with your medicine. Use of aranesp in these age groups is supported by evidence from adequate and wellcontrolled studies of aranesp in adults with additional data from a randomized trial evaluating two schedules weekly and every 2 week dosing in 114 pediatric patients 1 to 16 years of age receiving darbepoetin alfa, and an observational registry study in 319. Aranesp 500 micrograme, 1 seringa preumpluta, amgen. Product information aranesp darbepoetin alfa cds v28 19112019 page 6 of 32 patients with nonmyeloid malignancies receiving chemotherapy treatment should not be commenced unless haemoglobin falls below 100110 gl. This randomized, openlabel, crossover study was conducted to determine the pharmacokinetic profile of darbepoetin alfa in pediatric patients with ckd. Due to differences in global labelling, this information is intended for residents of canada only. Aarp health insurance plans pdf download medicare replacement pdf download medicare benefits pdf download medicare part b pdf download maximum dose of aranesp. Nov 03, 2014 medicare supplemental insurance pdf download medicare coverage pdf download medicare supplement plans pdf download aarp life insurance pdf download aarp insurance pdf download medicare part d pdf download medicare part b pdf download aranesp equivalent to recormon. Highlights of prescribing information these highlights do not include all the information needed to use aranespsafely and effectively. Adobe portable document format pdf is a universal file format that. Aarp health insurance plans pdf download medicare replacement pdf download medicare benefits pdf download medicare coverage pdf download medicare part d pdf download medicare part b pdf download benefits of convering to aranesp. Limitations of use aranesp has not been shown to improve. Anaemia is when your blood does not contain enough red blood cells and the symptoms may be fatigue, weakness and shortness of breath. Aranesp is available in singledose vials and prefilled syringes, except the 10, 150, and 500 mcg dose strengths, which are available only as prefilled syringes.
The iv route of administration is recommended for adult patients on hemodialysis. Darbepoetin alfa use has been reported in 7 children with chronic renal failure crf. This is my own transcription of bachs masterpiece and not a copy of any other arrangement with all due respect for segovias great arrangement. Aranesp can increase your risk of lifethreatening heart or circulation problems, including heart attack or stroke.
Instructions for use aranesp airuhnesp darbepoetin alfa. These resources are available to help you manage your anemia and chronic kidney disease. Do not use the prefilled syringe if the pack is damaged. Download free adobe acrobat reader dc software for your windows, mac os and android devices to view, print, and comment on pdf documents. Aranesp darbepoetin alfa injection, for intravenous or subcutaneous use initial u. Chronic kidney disease ckd in patients on dialysis and. Darbepoetin alfa is used to treat anemia caused by chemotherapy or chronic kidney disease. Aranesp for anaemia of renal failure darbepoetin alfa. Aranesp darbepoetin alfa aranesp fep clinical rationale rationale for inclusion in pa program background aranesp is an erythropoiesis stimulating agent esa that binds to progenitor stem cells and stimulates the production and differentiation of red blood cells rbc. Aranesp is used to treat anaemia low redbloodcell counts that is causing symptoms. Read this leaflet carefully before you start aranesp and keep it with the medicine. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. A lot of work went into this edition and i hope youll will app. Download free acrobat reader dc software, the only pdf viewer that lets you read, search, print, and interact with virtually any type of pdf file.
If that doesnt work, youll need adobe reader version 6. The manufacturer of the drug also filed an application with the fda on september 18, 2001, to receive an indication for treatment of anemia in patients with cancer robert hunter, amgen medical. If you have any concerns about using this medicine, ask your doctor, nurse or pharmacist. During the first several months of therapy, blood pressure and the presence of premonitory neurologic symptoms should be monitored closely. Aranesp increases the risk for seizures in patients with ckd 5. Do not try to warm the prefilled syringe by using a heat source such as hot water or microwave. Aranesp darbepoetin alfa therapy for oncology patients. Individualize dosing and use the lowest dose of aranesp sufficient to reduce the. This often occurs in people with chronic kidney failure whose kidneys are not working properly.
Aranesp exists in various strengths, from 25 to 500 micrograms per millilitre. Aranesp product monograph page 8 of 50 neurologic seizures use with caution in patients with a history of seizures. Canadian regulations limit the amount and scope of information we can provide on our prescription drugs. If the body does not produce enough red blood cells, severe anemia can occur. Epoetin and darbepoetin for managing anemia in patients. Aranesp has also been compared with placebo a dummy treatment in two studies involving 669 patients receiving chemotherapy for cancer such as lung cancer, myeloma or lymphoma.
Some of the dosage forms listed on this page may not apply to the brand name aranesp. Winner of the standing ovation award for best powerpoint templates from presentations magazine. The following table provides the prescribing information for amgen canadas major approved products. Mar 15, 2019 darbepoetin alfa is injected under the skin, or given as an infusion into a vein. Aranesp is contraindicated in patients with uncontrolled hypertension. Aranesp will help your bone marrow to produce more red blood cells, like your natural erythropoietin. Availability of presentations may vary in national regions.
Aranesp darbepoetin alfa rationale for inclusion in pa program. Apr 5, 2004 darbepoetin alfa aranesp and epoetin alfa. Conversion from epoetin alfa to aranesp in patients with ckd on dialysis administer aranesp once weekly in patients who were receiving epoetin alfa 2 to 3 label pdf fda. Pdf purification and characterization of recombinant. Aranesp has not been shown to improve quality of life, fatigue, or patient wellbeing 1. Aranesp darbepoetin alfa side effects, images, uses, dosage. Darbepoetin may be used for patients on kidney dialysis or for those not on dialysis. The main measure of effectiveness was the reduction in number of patients who needed a blood transfusion. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. For further information call emc accessibility on 0800 198 5000. The free acrobat reader is easy to download and can be freely distributed by anyone. Amgen support and services aranesp darbepoetin alfa. Seizures have occurred in patients participating in clinical trials of aranesp and rhuepo.
Do the following before you give yourself a subcutaneous injection of aranesp. Of the 347 patients randomized to aranesp, 92% were receiving hemodialysis and 8% were receiving peritoneal dialysis. Dailymed aranesp darbepoetin alfa injection, solution. Highlights of prescribing information these highlights do not. Following iv administration to these patients, aranesp serum. The original leaflet can be viewed using the link above.
Darbepoetin alfa may also be used for purposes not listed in this medication guide. Jan 01, 2017 darbepoetin alfa injection causes the bone marrow to produce red blood cells. It is used to treat anemia caused by chronic kidney failure and chemotherapy. Your doctor has given you aranesp to treat your anaemia. Free download, borrow, and streaming internet archive. Aranesp solution for injection drug information, side. Download leaflet view the patient leaflet in pdf format below is a text only representation of the patient information leaflet. Initiate esa treatment when the hemoglobin level is pdf download medicare coverage pdf download medicare supplement plans pdf download aarp life insurance pdf download aarp insurance pdf download medicare part d pdf download medicare part b pdf download aranesp equivalent to recormon. Download fulltext pdf purification and characterization of recombinant darbepoetin alfa from leishmania tarentolae article pdf available in molecular biotechnology 5889 june 2016 with 289. The fda requires this warning when there is a significant risk of serious or lifethreatening effects that anyone taking the drug should consider. In patients with cancer receiving hormonal agents, biologic products, or radiotherapy, unless also receiving concomitant myelosuppressive. Find patient medical information for aranesp in albumin injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. For a full dose, go directly to step 3, and choose between the subcutaneous or port injection based on your healthcare providers instructions.
The text only version may be available in large print, braille or audio cd. The food and drug administration fda approved darbepoetin alfa aranesp for treatment of anemia as sociated with chronic renal failure crf in patients on dialysis and patients not on dialysis. Highlights of prescribing information these highlights do. Instrumentation mixed chorus satb external links bibliotecamusica. Name of drug strength ndc price effective february 1, 2017 feb 1, 2017 aranesp. Our objective was to evaluate the efficacy and safety of darbepoetin and.
If you are prescribed a full dose of aranesp, you will inject all of the medicine from your prefilled syringe. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. The original pack with any unused prefilled syringes should remain in the refrigerator. Aranesp darbepoetin alfa is an erythropoiesisstimulating protein that is produced in chinese hamster ovary cho cells by recombinant dna technology. Vitali chaconne sheet music for violin and piano pdf.
Darbepoetin alfa aranesp in children with chronic renal. Renub research report japan proton therapy market, patients by 10 cancer types central nervous system cns, head and neck, lung, gi gastrointestinal, hepatocellular carcinoma hcc, pancreas, gynecologic, prostate, bone and soft tissue, others. Aranesp is a 165amino acid protein that differs from recombinant human erythropoietin in containing 5 nlinked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. Aranesp 10 micrograms solution for injection in prefilled syringe. Allergies to other erythropoietin products, aranesp, medicines made using. Aranesp darbepoetin alfa rationale for inclusion in. Find out what health conditions may be a health risk when taken with aranesp in albumin injection. Aarp health insurance plans pdf download medicare replacement pdf download medicare benefits pdf download medicare part b pdf download how much does aranesp cost. Count slowly to 15 you may hear a second click as the red button pops back up. Aranesp and other esas increased the risks for death, serious cardiovascular events, and stroke in controlled clinical trials of patients with cancer. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for aranesp darbepoetin alfa skip to. Find a comfortable, welllit, clean surface and put all the equipment. Monitor patients closely for newonset seizures, premonitory symptoms, or change in seizure frequency. You may be able to view a pdf document by just doubleclicking it.
Ask your doctor if you have any questions about why aranesp has been prescribed for you. Aranesp may be administered as a subcutaneous sc injection. Your doctor has given you aranesp an antianaemic to treat your anaemia. Webmd provides common contraindications for aranesp in albumin injection. The findings and conclusions in this document are those of the authors, who are. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for aranesp darbepoetin alfa. Darbepoetin alfa is a manmade form of a protein that helps your body produce red blood cells. Aranesp has been used for over 10 years to treat patients with chronic kidney disease on dialysis and patients not on dialysis. It stimulates erythropoiesis increases red blood cell levels by the same. Aranesp is a solution for injection in a vial, a prefilled syringe or a prefilled pen. Prepare a remove one prefilled syringe from the refrigerator. The effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.
Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Aranesp darbepoetin alfa can raise your chance of death by blood clots. Increase monitoring of these patients for changes in seizure frequency or premonitory symptoms 5. Do not leave the prefilled pen exposed to direct sunlight. Instructions for use aranesp airuhnesp darbepoetin. It has a 3fold longer serum halflife compared to epoetin alpha and epoetin beta. Darbepoetin alfa is used to treat anemia caused by chemotherapy or chronic kidney disease darbepoetin alfa may also be used for purposes not listed in this medication guide. Aranesp is an erythropoiesisstimulating agent esa indicated for the treatment of anemia due to. Aranesp darbepoetin alfa side effects, images, uses. Chronic kidney disease ckd in patients on dialysis and patients not on dialysis. Before you use it when you must not use aranesp do not use aranesp if you have. Aranesp for anaemia of renal failure darbepoetin alfa drug. This document contains side effect information about darbepoetin alfa. Darbepoetin alfa injection causes the bone marrow to produce red blood cells.
High blood pressure that is not controlled by other medicines. Fingerings are well thought out and clearly stated. Pdf digital sheet music to download and print, interactive sheet music for online playing, transposition and printing, midi and mp3 audio files including mp3 music accompaniment tracks to play along once you buy or access this item as a member, youll be able to download everything included as a single. If you are prescribed a partial dose of aranesp, start with step g below. If severe anemia and low reticulocyte count develop during aranesp treatment, withhold aranesp and evaluate for prca 5. The haemoglobin target, regardless of the treatment population, should not exceed 120 gl see section 4. Aranesp sureclick patient information leaflet pil emc. Aranesp is also available in 150, 200, 300, and 500 mcg dose strengths. Aranesp has extensive clinical experience with proven option for patients. To prevent this, make sure youre regularly seeing your doctor and getting blood tests. Do not leave the prefilled syringe in direct sunlight.
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